Reaction Details Report a problem with these data
Target
Tumor necrosis factor receptor superfamily member 16
Ligand
BDBM50111443
Substrate
n/a
Meas. Tech.
ChEMBL_144432 (CHEMBL753642)
IC50
3720±n/a nM
Citation
 Toogood, PL Inhibition of protein-protein association by small molecules: approaches and progress. J Med Chem 45:1543-58 (2002) [PubMed]  Article 
Target
Name:
Tumor necrosis factor receptor superfamily member 16
Synonyms:
CD_antigen=CD271 | Gp80-LNGFR | Low affinity neurotrophin receptor p75NTR | Low-affinity nerve growth factor receptor | NGF receptor | NGFR | TNFRSF16 | TNR16_HUMAN | Tumor necrosis factor receptor superfamily member 16 | p75 ICD
Type:
PROTEIN
Mol. Mass.:
45159.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_346884
Residue:
427
Sequence:
MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPV
  
Inhibitor
Name:
BDBM50111443
Synonyms:
2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquinoline-1,3-dione(ALE-0540) | CHEMBL440470
Type:
Small organic molecule
Emp. Form.:
C14H11N3O5
Mol. Mass.:
301.2542
SMILES:
OCCNN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O
Structure:
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