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Target
NH(3)-dependent NAD(+) synthetase
Ligand
BDBM50130812
Substrate
n/a
Meas. Tech.
ChEMBL_141613 (CHEMBL747929)
IC50
10000±n/a nM
Citation
 Velu, SE; Cristofoli, WA; Garcia, GJ; Brouillette, CG; Pierson, MC; Luan, CH; DeLucas, LJ; Brouillette, WJ Tethered dimers as NAD synthetase inhibitors with antibacterial activity. J Med Chem 46:3371-81 (2003) [PubMed]  Article 
Target
Name:
NH(3)-dependent NAD(+) synthetase
Synonyms:
GSP38 | General stress protein 38 | NADE_BACSU | Spore outgrowth factor B | Sporulation protein outB | nadE | outB
Type:
PROTEIN
Mol. Mass.:
30386.77
Organism:
Bacillus subtilis
Description:
ChEMBL_141613
Residue:
272
Sequence:
MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVLGISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDKSWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDHAAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQQSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK
  
Inhibitor
Name:
BDBM50130812
Synonyms:
4-[8-(5-Benzyloxy-2-methoxycarbonyl-indol-1-yl)-octyloxycarbonyl]-1-methyl-pyridinium; iodide | CHEMBL325468
Type:
Small organic molecule
Emp. Form.:
C32H37N2O5
Mol. Mass.:
529.646
SMILES:
COC(=O)c1cc2cc(OCc3ccccc3)ccc2n1CCCCCCCCOC(=O)c1cc[n+](C)cc1
Structure:
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