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Target
Major prion protein
Ligand
BDBM50131720
Substrate
n/a
Meas. Tech.
ChEMBL_158887 (CHEMBL760875)
EC50
>10000±n/a nM
Citation
 Vogtherr, M; Grimme, S; Elshorst, B; Jacobs, DM; Fiebig, K; Griesinger, C; Zahn, R Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. J Med Chem 46:3563-4 (2003) [PubMed]  Article 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM50131720
Synonyms:
9,10-diazaanthracene | CHEMBL119870 | acridizine | azophenylene | dibenzo-p-diazine | dibenzoparadiazine | dibenzopyrazine | phenazine
Type:
Small organic molecule
Emp. Form.:
C12H8N2
Mol. Mass.:
180.2053
SMILES:
c1ccc2nc3ccccc3nc2c1
Structure:
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