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Target
MO15-related protein kinase Pfmrk
Ligand
BDBM4291
Substrate
n/a
Meas. Tech.
ChEMBL_52684 (CHEMBL666139)
IC50
5100±n/a nM
Citation
 Woodard, CL; Li, Z; Kathcart, AK; Terrell, J; Gerena, L; Lopez-Sanchez, M; Kyle, DE; Bhattacharjee, AK; Nichols, DA; Ellis, W; Prigge, ST; Geyer, JA; Waters, NC Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases. J Med Chem 46:3877-82 (2003) [PubMed]  Article 
Target
Name:
MO15-related protein kinase Pfmrk
Synonyms:
Protein kinase Pfmrk
Type:
PROTEIN
Mol. Mass.:
37992.30
Organism:
Plasmodium falciparum
Description:
ChEMBL_640752
Residue:
324
Sequence:
MENNSTERYIFKPNFLGEGSYGKVYKAYDTILKKEVAIKKMKLNEISNYIDDCGINFVLLREIKIMKEIKHKNIMSALDLYCEKDYINLVMEIMDYDLSKIINRKIFLTDSQKKCILLQILNGLNVLHKYYFMHRDLSPANIFINKKGEVKLADFGLCTKYGYDMYSDKLFRDKYKKNLNLTSKVVTLWYRAPELLLGSNKYNSSIDMWSFGCIFAELLLQKALFPGENEIDQLGKIFFLLGTPNENNWPEALCLPLYTEFTKATKKDFKTYFKIDDDDCIDLLTSFLKLNAHERISAEDAMKHRYFFNDPLPCDISQLPFNDL
  
Inhibitor
Name:
BDBM4291
Synonyms:
(2-Oxo-3-indolinidene)malononitrile | 2-(2-oxo-2,3-dihydro-1H-indol-3-ylidene)propanedinitrile | CHEMBL293798 | Tyrphostin deriv. 22
Type:
Small organic molecule
Emp. Form.:
C11H5N3O
Mol. Mass.:
195.1769
SMILES:
O=[#6]1-[#7]-c2ccccc2\[#6]-1=[#6](/C#N)C#N
Structure:
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