Reaction Details Report a problem with these data
Target
Histamine H4 receptor
Ligand
BDBM50133004
Substrate
n/a
Meas. Tech.
ChEMBL_87231 (CHEMBL696451)
Ki
3.3±n/a nM
Citation
 Jablonowski, JA; Grice, CA; Chai, W; Dvorak, CA; Venable, JD; Kwok, AK; Ly, KS; Wei, J; Baker, SM; Desai, PJ; Jiang, W; Wilson, SJ; Thurmond, RL; Karlsson, L; Edwards, JP; Lovenberg, TW; Carruthers, NI The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem 46:3957-60 (2003) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
HH4R | HRH4_RAT | Hrh4
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44045.07
Organism:
Rattus norvegicus (rat)
Description:
Cell pellets from SK-N-MC cells transfected with rat H4 receptor were used in binding assay.
Residue:
391
Sequence:
MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
  
Inhibitor
Name:
BDBM50133004
Synonyms:
(7-Amino-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone | (7-amino-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone | CHEMBL129540
Type:
Small organic molecule
Emp. Form.:
C14H18N4O
Mol. Mass.:
258.3189
SMILES:
CN1CCN(CC1)C(=O)c1cc2cccc(N)c2[nH]1
Structure:
Search PDB for entries with ligand similarity: