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Target
Nuclear receptor subfamily 1 group I member 3
Ligand
BDBM8885
Substrate
n/a
Meas. Tech.
ChEMBL_48049 (CHEMBL666774)
IC50
30000±n/a nM
Citation
 Jyrkkärinne, J; Mäkinen, J; Gynther, J; Savolainen, H; Poso, A; Honkakoski, P Molecular determinants of steroid inhibition for the mouse constitutive androstane receptor. J Med Chem 46:4687-95 (2003) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group I member 3
Synonyms:
Car | Constitutive androstane receptor | NR1I3_MOUSE | Nr1i3 | Nuclear receptor subfamily 1 group I member 3 | Orphan nuclear receptor MB67
Type:
PROTEIN
Mol. Mass.:
40922.30
Organism:
Mus musculus
Description:
ChEMBL_48051
Residue:
358
Sequence:
MTAMLTLETMASEEEYGPRNCVVCGDRATGYHFHALTCEGCKGFFRRTVSKTIGPICPFAGRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRARQAQRRAEKASLQLNQQQKELVQILLGAHTRHVGPMFDQFVQFKPPAYLFMHHRPFQPRGPVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTFCLQTENFFCGPLCYKMEDAVHAGFQYEFLESILHFHKNLKGLHLQEPEYVLMAATALFSPDRPGVTQREEIDQLQEEMALILNNHIMEQQSRLQSRFLYAKLMGLLADLRSINNAYSYELQRLEELSAMTPLLGEICS
  
Inhibitor
Name:
BDBM8885
Synonyms:
(1S,2R,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one | 17beta-Hydroxyandrost-4-en-3-one | Testosterone | Testosterone, 1 | US9682960, Testosterone
Type:
Steroid
Emp. Form.:
C19H28O2
Mol. Mass.:
288.4244
SMILES:
[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C |r,t:18|
Structure:
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