Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50123974
Substrate
n/a
Meas. Tech.
ChEMBL_87857 (CHEMBL701995)
IC50
200±n/a nM
Citation
 Miller, TA; Witter, DJ; Belvedere, S Histone deacetylase inhibitors. J Med Chem 46:5097-116 (2003) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50123974
Synonyms:
CHEMBL149534 | N-Hydroxy-3-(4-p-tolylsulfamoyl-phenyl)-acrylamide | US8796330, 161
Type:
Small organic molecule
Emp. Form.:
C16H16N2O4S
Mol. Mass.:
332.374
SMILES:
Cc1ccc(NS(=O)(=O)c2ccc(\C=C\C(=O)NO)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: