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TargetNicotinic acetylcholine receptor alpha1/beta1/gamma/delta
LigandBDBM50125934
Substrate/Competitorn/a
Meas. Tech.ChEMBL_144957
IC50 25000±n/a nM
Citation Husain, SSZiebell, MRRuesch, DHong, FArevalo, EKosterlitz, JAOlsen, RWForman, SACohen, JBMiller, KW 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels. J Med Chem46:1257-65 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nicotinic acetylcholine receptor alpha1/beta1/gamma/delta
Name:Nicotinic acetylcholine receptor alpha1/beta1/gamma/delta
Synonyms:n/a
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 144957
Components:This complex has 4 components.
Component 1
Name:n-AChR
Synonyms:Acetylcholine receptor subunit alpha
Type:Enzyme Catalytic Domain
Mol. Mass.:51932.98
Organism:MOUSE
Description:n-AChR 0 MOUSE::P04756
Residue:457
Sequence:
MELSTVLLLLGLCSAGLVLGSEHETRLVAKLFEDYSSVVRPVEDHREIVQVTVGLQLIQL
INVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDF
AIVKFTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINP
ESDQPDLSNFMESGEWVIKEARGWKHWVFYSCCPTTPYLDITYHFVMQRLPLYFIVNVII
PCLLFSFLTSLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLF
TMVFVIASIIITVIVINTHHRSPSTHIMPEWVRKVFIDTIPNIMFFSTMKRPSRDKQEKR
IFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGVKYIAETMKSDQESNNAAEEWK
YVAMVMDHILLGVFMLVCLIGTLAVFAGRLIELHQQG
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Component 2
Name:Acetylcholine receptor protein beta chain
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:56919.84
Organism:Mus musculus
Description:EBI_11803
Residue:501
Sequence:
MALGALLLLLGVLGTPLAPGARGSEAEGQLIKKLFSNYDSSVRPAREVGDRVGVSIGLTL
AQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNND
GNFDVALDINVVVSFEGSVRWQPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVS
LKTGLDPEGEERQEVYIHEGTFIENGQWEIIHKPSRLIQLPGDQRGGKEGHHEEVIFYLI
IRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPE
TSLAVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPFWVRQIFIHKLPPYLGL
KRPKPERDQLPEPHHSLSPRSGWGRGTDEYFIRKPPSDFLFPKLNRFQPESSAPDLRRFI
DGPTRAVGLPQELREVISSISYMARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIVFTS
VGTLVIFLDATYHLPPPEPFP
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Component 3
Name:Acetylcholine receptor subunit gamma
Synonyms:Acetylcholine receptor subunit gamma | Acrg | Chrng
Type:PROTEIN
Mol. Mass.:58747.23
Organism:Mus musculus
Description:ChEMBL_107886
Residue:519
Sequence:
MQGGQRPHLLLLLLAVCLGAQSRNQEERLLADLMRNYDPHLRPAERDSDVVNVSLKLTLT
NLISLNEREEALTTNVWIEMQWCDYRLRWDPKDYEGLWILRVPSTMVWRPDIVLENNVDG
VFEVALYCNVLVSPDGCIYWLPPAIFRSSCSISVTYFPFDWQNCSLIFQSQTYSTSEINL
QLSQEDGQAIEWIFIDPEAFTENGEWAIRHRPAKMLLDSVAPAEEAGHQKVVFYLLIQRK
PLFYVINIIAPCVLISSVAILIYFLPAKAGGQKCTVATNVLLAQTVFLFLVAKKVPETSQ
AVPLISKYLTFLMVVTILIVVNSVVVLNVSLRSPHTHSMARGVRKLFLRLLPQLLRMHVR
PLAPAAVQDARFRLQNGSSSGWPIMAREEGDLCLPRSELLFRQRQRNGLVQAVLEKLENG
PEVRQSQEFCGSLKQASPAIQACVDACNLMARARRQQSHFDSGNEEWLLVGRVLDRVCFL
AMLSLFICGTAGIFLMAHYNQVPDLPFPGDPRPYLPLPD
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Component 4
Name:Acetylcholine receptor protein delta chain
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:59138.17
Organism:Mus musculus
Description:EBI_100149
Residue:520
Sequence:
MAGPVLTLGLLAALVVCALPGSWGLNEEQRLIQHLFNEKGYDKDLRPVARKEDKVDVALS
LTLSNLISLKEVEETLTTNVWIDHAWVDSRLQWDANDFGNITVLRLPPDMVWLPEIVLEN
NNDGSFQISYACNVLVYDSGYVTWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAK
EITLSLKQEEENNRSYPIEWIIIDPEGFTENGEWEIVHRAAKLNVDPSVPMDSTNHQDVT
FYLIIRRKPLFYIINILVPCVLISFMINLVFYLPGDCGEKTSVAISVLLAQSVFLLLISK
RLPATSMAIPLVGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKFFLETLPK
LLHMSRPAEEDPGPRALIRRSSSLGYICKAEEYFSLKSRSDLMFEKQSERHGLARRLTTA
RRPPASSEQVQQELFNEMKPAVDGANFIVNHMRDQNSYNEEKDNWNQVARTVDRLCLFVV
TPVMVVGTAWIFLQGVYNQPPLQPFPGDPFSYSEQDKRFI
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BDBM50125934
NameBDBM50125934
Synonyms:3-(1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid 2-(3-methyl-3H-diazirin-3-yl)-ethyl ester | CHEMBL23812
TypeSmall organic molecule
Emp. Form.n/a
Mol. Mass.n/a
SMILESn/a
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a