Target
Cyclin-dependent kinase 2
Ligand
BDBM7683
Substrate
n/a
Meas. Tech.
ChEMBL_50507 (CHEMBL661124)
IC50
360±n/a nM
Citation
 Tominaga, YJorgensen, WL General model for estimation of the inhibition of protein kinases using Monte Carlo simulations. J Med Chem 47:2534-49 (2004) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM7683
Synonyms:
4-({1-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]ethyl}amino)benzene-1-sulfonamide | 4-{[1-(2-Oxo-1,2-dihydro-3H-indol-3-ylidene)ethyl]-amino}benzenesulfonamide | Oxindole-Based Inhibitor 19
Type:
Small organic molecule
Emp. Form.:
C16H15N3O3S
Mol. Mass.:
329.374
SMILES:
CC(=Nc1ccc(cc1)S(N)(=O)=O)C1C(=O)Nc2ccccc12 |w:2.2|
Structure:
Search PDB for entries with ligand similarity: