Reaction Details Report a problem with these data
Target
6-phosphogluconate dehydrogenase, decarboxylating
Ligand
BDBM50148778
Substrate
n/a
Meas. Tech.
ChEMBL_4339 (CHEMBL619158)
Ki
714000±n/a nM
Citation
 Dardonville, C; Rinaldi, E; Barrett, MP; Brun, R; Gilbert, IH; Hanau, S Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues. J Med Chem 47:3427-37 (2004) [PubMed]  Article 
Target
Name:
6-phosphogluconate dehydrogenase, decarboxylating
Synonyms:
6-phosphogluconate dehydrogenase | 6-phosphogluconate dehydrogenase (6PGD) | 6PGD_HUMAN | PGD | PGDH
Type:
Protein
Mol. Mass.:
53143.42
Organism:
Homo sapiens (Human)
Description:
P52209
Residue:
483
Sequence:
MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSSYNA
  
Inhibitor
Name:
BDBM50148778
Synonyms:
CHEMBL114894 | Phosphoric acid mono-((R)-(R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl) ester
Type:
Small organic molecule
Emp. Form.:
C7H14NO7P
Mol. Mass.:
255.1623
SMILES:
CC1(C)O[C@H](COP(O)(O)=O)[C@@H](O1)C(N)=O
Structure:
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