Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50150076
Substrate
n/a
Meas. Tech.
ChEMBL_31079 (CHEMBL640610)
EC50
9±n/a nM
Citation
 Beukers, MW; Chang, LC; von Frijtag Drabbe Künzel, JK; Mulder-Krieger, T; Spanjersberg, RF; Brussee, J; IJzerman, AP New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine. J Med Chem 47:3707-9 (2004) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50150076
Synonyms:
2-((1H-imidazol-2-yl)methylthio)-6-amino-4-(4-methoxyphenyl)pyridine-3,5-dicarbonitrile | 2-Amino-6-(1H-imidazol-2-ylmethylsulfanyl)-4-(4-methoxy-phenyl)-pyridine-3,5-dicarbonitrile | CHEMBL122396
Type:
Small organic molecule
Emp. Form.:
C18H14N6OS
Mol. Mass.:
362.408
SMILES:
COc1ccc(cc1)-c1c(C#N)c(N)nc(SCc2ncc[nH]2)c1C#N
Structure:
Search PDB for entries with ligand similarity: