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Target
Potassium voltage-gated channel subfamily KQT member 1
Ligand
BDBM50099567
Substrate
n/a
Meas. Tech.
ChEMBL_88893 (CHEMBL694796)
IC50
39000±n/a nM
Citation
 Wermuth, CG Selective optimization of side activities: another way for drug discovery. J Med Chem 47:1303-14 (2004) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily KQT member 1
Synonyms:
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 | KCNQ1 | KCNQ1_CAVPO | KQT-like 1 | KVLQT1 | Potassium voltage-gated channel subfamily KQT member 1 | Voltage-gated potassium channel subunit Kv7.1
Type:
PROTEIN
Mol. Mass.:
74450.11
Organism:
Cavia porcellus
Description:
ChEMBL_88894
Residue:
671
Sequence:
MAAASSPPRTERKRGGWGRLLGSRRGSASLAKKCPFSLELAEGGPAGGTLYAPVAPPGALSPGSPAPPASPAAPPAGLELGPRPPVSLDPRVSIYSARRPLLARTHIQGRVYNFLERPTGWKCFVYHFAVFLIVLACLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYVRKPARSHTLLSPSPKPKKSAMVRKKKFKPDKDNGVSPGEKMLTVPHITCDPPEERRPDHFSVDGYDSSVRKSPTLLEVSPTHFMRTNSFAEDLDLEGETLLTPITHVSQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFIPISEKSKDRGSNTIGARLNRVEDKVTQLDQRLVVITDMLHQLLSLHQGGPHSGGGPQMVQPCSEDGSIHPELFLPSNSLPTYEQLTVPQRGPDEAS
  
Inhibitor
Name:
BDBM50099567
Synonyms:
(3S,4R)-Ethanesulfonic acid (6-cyano-3-hydroxy-2,2-dimethyl-chroman-4-yl)-methyl-amide | CHEMBL44297 | Ethanesulfonic acid (6-cyano-3-hydroxy-2,2-dimethyl-chroman-4-yl)-methyl-amide
Type:
Small organic molecule
Emp. Form.:
C15H20N2O4S
Mol. Mass.:
324.395
SMILES:
CCS(=O)(=O)N(C)[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C#N
Structure:
Search PDB for entries with ligand similarity: