Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM50143228
Substrate
n/a
Meas. Tech.
ChEMBL_37506 (CHEMBL648136)
Ki
4.91±n/a nM
Citation
 Primofiore, G; Da Settimo, F; Taliani, S; Simorini, F; Patrizi, MP; Novellino, E; Greco, G; Abignente, E; Costa, B; Chelli, B; Martini, C N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor. J Med Chem 47:1852-5 (2004) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50143228
Synonyms:
CHEMBL54066 | N,N-Dibutyl-2-(5-chloro-2-phenyl-1H-indol-3-yl)-2-oxo-acetamide
Type:
Small organic molecule
Emp. Form.:
C24H27ClN2O2
Mol. Mass.:
410.936
SMILES:
CCCCN(CCCC)C(=O)C(=O)c1c([nH]c2ccc(Cl)cc12)-c1ccccc1
Structure:
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