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Target
Translocator protein
Ligand
BDBM50144887
Substrate
n/a
Meas. Tech.
ChEMBL_154645 (CHEMBL760163)
Ki
18.1±n/a nM
Citation
 Zhang, MR; Maeda, J; Ogawa, M; Noguchi, J; Ito, T; Yoshida, Y; Okauchi, T; Obayashi, S; Suhara, T; Suzuki, K Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain. J Med Chem 47:2228-35 (2004) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50144887
Synonyms:
CHEMBL443526 | Toluene-4-sulfonic acid 2-(2-{[acetyl-(5-fluoro-2-phenoxy-phenyl)-amino]-methyl}-4-methoxy-phenoxy)-ethyl ester
Type:
Small organic molecule
Emp. Form.:
C31H30FNO7S
Mol. Mass.:
579.636
SMILES:
COc1ccc(OCCOS(=O)(=O)c2ccc(C)cc2)c(CN(C(C)=O)c2cc(F)ccc2Oc2ccccc2)c1
Structure:
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