Reaction Details Report a problem with these data
Target
RNA-directed RNA polymerase
Ligand
BDBM50144937
Substrate
n/a
Meas. Tech.
ChEMBL_84043 (CHEMBL691889)
IC50
600±n/a nM
Citation
Eldrup, AB; Allerson, CR; Bennett, CF; Bera, S; Bhat, B; Bhat, N; Bosserman, MR; Brooks, J; Burlein, C; Carroll, SS; Cook, PD; Getty, KL; MacCoss, M; McMasters, DR; Olsen, DB; Prakash, TP; Prhavc, M; Song, Q; Tomassini, JE; Xia, J Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem 47:2283-95 (2004) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50144937
Synonyms:
2-Amino-9-((2R,3R,5S)-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one | 9-(3-DEOXY-BETA-D-RIBOFURANOSYL)GUANINE | CHEMBL73502
Type:
Small organic molecule
Emp. Form.:
C10H13N5O4
Mol. Mass.:
267.2413
SMILES:
Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](CO)C[C@H]1O