Reaction Details Report a problem with these data
Target
Interleukin-2 receptor subunit alpha
Ligand
BDBM50147997
Substrate
n/a
Meas. Tech.
ChEMBL_89084 (CHEMBL878448)
IC50
50000±n/a nM
Citation
 Raimundo, BC; Oslob, JD; Braisted, AC; Hyde, J; McDowell, RS; Randal, M; Waal, ND; Wilkinson, J; Yu, CH; Arkin, MR Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem 47:3111-30 (2004) [PubMed]  Article 
Target
Name:
Interleukin-2 receptor subunit alpha
Synonyms:
CD_antigen=CD25 | IL-2 receptor alpha subunit | IL-2-RA | IL2-RA | IL2RA_MOUSE | Il2r | Il2ra | Interleukin-2 receptor alpha chain | p55
Type:
PROTEIN
Mol. Mass.:
30733.96
Organism:
Mus musculus
Description:
ChEMBL_89085
Residue:
268
Sequence:
MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNATFKALSYKNGTILNCECKRGFRRLKELVYMRCLGNSWSSNCQCTSNSHDKSRKQVTAQLEHQKEQQTTTDMQKPTQSMHQENLTGHCREPPPWKHEDSKRIYHFVEGQSVHYECIPGYKALQRGPAISICKMKCGKTGWTQPQLTCVDEREHHRFLASEESQGSRNSSPESETSCPITTTDFPQPTETTAMTETFVLTMEYKVAVASCLFLLISILLLSGLTWQHRWRKSRRTI
  
Inhibitor
Name:
BDBM50147997
Synonyms:
2-Cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-1-methyl-1H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethyl)-2-guanidino-acetamide | CHEMBL449094
Type:
Small organic molecule
Emp. Form.:
C26H35Cl2N7O2
Mol. Mass.:
548.508
SMILES:
[#6]-n1nc(cc1-c1cccc(Cl)c1Cl)-[#6]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](\[#7]=[#6](/[#7])-[#7])-[#6]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1
Structure:
Search PDB for entries with ligand similarity: