Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50150501
Substrate
n/a
Meas. Tech.
ChEMBL_305554 (CHEMBL828573)
IC50
3000±n/a nM
Citation
 Ueno, H; Katoh, S; Yokota, K; Hoshi, J; Hayashi, M; Uchida, I; Aisaka, K; Hase, Y; Cho, H Structure-activity relationships of potent and selective factor Xa inhibitors: benzimidazole derivatives with the side chain oriented to the prime site of factor Xa. Bioorg Med Chem Lett 14:4281-6 (2004) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50150501
Synonyms:
2-{4-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-phenoxymethyl}-1-(2-oxo-2-piperidin-1-yl-ethyl)-1H-benzoimidazole-5-carboxamidine; dihydrochloride | CHEMBL556192
Type:
Small organic molecule
Emp. Form.:
C29H37N7O3
Mol. Mass.:
531.6492
SMILES:
CC(=N)N1CCC(CC1)Oc1ccc(OCc2nc3cc(ccc3n2CC(=O)N2CCCCC2)C(N)=N)cc1
Structure:
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