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Target
Beta-1 adrenergic receptor
Ligand
BDBM50027167
Substrate
n/a
Meas. Tech.
ChEMBL_310554 (CHEMBL834455)
EC50
1.3±n/a nM
Citation
 Nakajima, Y; Hamashima, H; Washizuka, K; Tomishima, Y; Ohtake, H; Imamura, E; Miura, T; Kayakiri, H; Kato, M Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist. Bioorg Med Chem Lett 15:251-4 (2004) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50027167
Synonyms:
CHEMBL183283
Type:
Small organic molecule
Emp. Form.:
C26H29N3O6
Mol. Mass.:
479.525
SMILES:
OC[C@H](Cc1ccc(NC(=O)Nc2cccc(c2)C(O)=O)cc1)NC[C@H](O)COc1ccccc1
Structure:
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