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Target
Carbonic anhydrase 2
Ligand
BDBM50157956
Substrate
n/a
Meas. Tech.
ChEMBL_303334 (CHEMBL840150)
Ki
104±n/a nM
Citation
 Turkmen, H; Durgun, M; Yilmaztekin, S; Emul, M; Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX. Bioorg Med Chem Lett 15:367-72 (2004) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50157956
Synonyms:
4-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-butyramide | CHEMBL360041
Type:
Small organic molecule
Emp. Form.:
C14H21N3O4S
Mol. Mass.:
327.399
SMILES:
NS(=O)(=O)c1ccc(NC(=O)CCCN2CCOCC2)cc1
Structure:
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