Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50164934
Substrate
n/a
Meas. Tech.
ChEMBL_303552 (CHEMBL828952)
Ki
10±n/a nM
Citation
 Mazurov, A; Klucik, J; Miao, L; Phillips, TY; Seamans, A; Schmitt, JD; Hauser, TA; Johnson, RT; Miller, C 2-(Arylmethyl)-3-substituted quinuclidines as selective alpha 7 nicotinic receptor ligands. Bioorg Med Chem Lett 15:2073-7 (2005) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50164934
Synonyms:
(4-Bromo-phenyl)-carbamic acid (2R,3R)-2-imidazol-1-ylmethyl-1-aza-bicyclo[2.2.2]oct-3-yl ester | CHEMBL193743
Type:
Small organic molecule
Emp. Form.:
C18H21BrN4O2
Mol. Mass.:
405.289
SMILES:
Brc1ccc(NC(=O)O[C@@H]2C3CCN(CC3)[C@@H]2Cn2ccnc2)cc1 |wU:9.8,16.18,(17.32,1.56,;15.98,2.33,;14.64,1.56,;13.31,2.33,;13.32,3.89,;11.99,4.66,;10.65,3.89,;10.65,2.35,;9.32,4.66,;7.99,3.89,;6.66,4.67,;5.88,3.34,;7.21,2.57,;6.66,1.59,;5.33,2.35,;5.33,3.89,;7.99,2.35,;9.32,1.58,;9.32,.04,;10.57,-.85,;10.09,-2.32,;8.55,-2.32,;8.07,-.85,;14.65,4.64,;15.98,3.89,)|
Structure:
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