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TargetEukaryotic translation initiation factor 4E (eIF4E)
LigandBDBM50370489
Substrate/Competitorn/a
Meas. Tech.ChEMBL_305877
IC50>400000±n/a nM
Citation Ghosh, PPark, CPeterson, MSBitterman, PBPolunovsky, VAWagner, CR Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP. Bioorg Med Chem Lett15:2177-80 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Eukaryotic translation initiation factor 4E (eIF4E)
Name:Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1
Synonyms:Eukaryotic translation initation factor
Type:Protein
Mol. Mass.:25095.44
Organism:Homo sapiens (Human)
Description:P06730
Residue:217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
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BDBM50370489
NameBDBM50370489
Synonyms:CHEMBL607902
TypeSmall organic molecule
Emp. Form.C11H17N5O4S
Mol. Mass.315.349
SMILESCN1CN(C2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=S)c12 |r|
Structure
n/a