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Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50370489
Substrate
n/a
Meas. Tech.
ChEMBL_305877 (CHEMBL831921)
IC50
>400000±n/a nM
Citation
 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP. Bioorg Med Chem Lett 15:2177-80 (2005) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN
Type:
Protein
Mol. Mass.:
25095.44
Organism:
Homo sapiens (Human)
Description:
P06730
Residue:
217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50370489
Synonyms:
CHEMBL607902
Type:
Small organic molecule
Emp. Form.:
C11H17N5O4S
Mol. Mass.:
315.349
SMILES:
CN1CN(C2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=S)c12 |r|
Structure:
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