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TargetTubulin
LigandBDBM50060957
Substrate/Competitorn/a
Meas. Tech.ChEMBL_311702
IC50 5300±n/a nM
Citation Edsall, ABMohanakrishnan, AKYang, DFanwick, PEHamel, EHanson, ADAgoston, GECushman, M Effects of altering the electronics of 2-methoxyestradiol on cell proliferation, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization. J Med Chem47:5126-39 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tubulin
Name:Tubulin
Synonyms:Tubulin beta chain
Type:PROTEIN
Mol. Mass.:49932.38
Organism:Bos taurus
Description:ChEMBL_211651
Residue:445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50060957
NameBDBM50060957
Synonyms:2-Hydroxyestradol 2-methyl ether | 2-methoxy-17beta-estradiol | CHEMBL299613 | Panzem
TypeSmall organic molecule
Emp. Form.C19H26O3
Mol. Mass.302.4079
SMILESCOc1cc2[C@H]3CC[C@]4(C)[C@@H](O)CC[C@H]4[C@@H]3CCc2cc1O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a