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Target
MO15-related protein kinase Pfmrk
Ligand
BDBM50154616
Substrate
n/a
Meas. Tech.
ChEMBL_306159 (CHEMBL832347)
IC50
4700±n/a nM
Citation
 Bhattacharjee, AK; Geyer, JA; Woodard, CL; Kathcart, AK; Nichols, DA; Prigge, ST; Li, Z; Mott, BT; Waters, NC A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. J Med Chem 47:5418-26 (2004) [PubMed]  Article 
Target
Name:
MO15-related protein kinase Pfmrk
Synonyms:
Protein kinase Pfmrk
Type:
PROTEIN
Mol. Mass.:
37992.30
Organism:
Plasmodium falciparum
Description:
ChEMBL_640752
Residue:
324
Sequence:
MENNSTERYIFKPNFLGEGSYGKVYKAYDTILKKEVAIKKMKLNEISNYIDDCGINFVLLREIKIMKEIKHKNIMSALDLYCEKDYINLVMEIMDYDLSKIINRKIFLTDSQKKCILLQILNGLNVLHKYYFMHRDLSPANIFINKKGEVKLADFGLCTKYGYDMYSDKLFRDKYKKNLNLTSKVVTLWYRAPELLLGSNKYNSSIDMWSFGCIFAELLLQKALFPGENEIDQLGKIFFLLGTPNENNWPEALCLPLYTEFTKATKKDFKTYFKIDDDDCIDLLTSFLKLNAHERISAEDAMKHRYFFNDPLPCDISQLPFNDL
  
Inhibitor
Name:
BDBM50154616
Synonyms:
2-Fluoro-4b,9,10-triaza-benzo[b]fluorene-5,11-dione | 4-aza-8-fluorotryptanthrin | CHEMBL187652 | US10669273, Compound CY-1-2
Type:
Small organic molecule
Emp. Form.:
C14H6FN3O2
Mol. Mass.:
267.2147
SMILES:
Fc1ccc-2c(c1)C(=O)c1nc3ncccc3c(=O)n-21
Structure:
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