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Target
Tubulin beta-1 chain
Ligand
BDBM50168445
Substrate
n/a
Meas. Tech.
ChEMBL_305173 (CHEMBL832762)
IC50
1100±n/a nM
Citation
 Pettit, GR; Rhodes, MR; Herald, DL; Hamel, E; Schmidt, JM; Pettit, RK Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. J Med Chem 48:4087-99 (2005) [PubMed]  Article 
Target
Name:
Tubulin beta-1 chain
Synonyms:
TBB1_HUMAN | TUBB1
Type:
PROTEIN
Mol. Mass.:
50311.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305173
Residue:
451
Sequence:
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
  
Inhibitor
Name:
BDBM50168445
Synonyms:
5-[(Z)-2-(3-Bromo-4-methoxy-phenyl)-vinyl]-1,2,3-trimethoxy-benzene | CHEMBL192860
Type:
Small organic molecule
Emp. Form.:
C18H19BrO4
Mol. Mass.:
379.245
SMILES:
COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1Br
Structure:
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