Reaction Details Report a problem with these data
Target
S-methyl-5'-thioadenosine phosphorylase
Ligand
BDBM50170092
Substrate
n/a
Meas. Tech.
ChEMBL_302838 (CHEMBL827883)
Ki
0.36±n/a nM
Citation
 Evans, GB; Furneaux, RH; Lenz, DH; Painter, GF; Schramm, VL; Singh, V; Tyler, PC Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J Med Chem 48:4679-89 (2005) [PubMed]  Article 
Target
Name:
S-methyl-5'-thioadenosine phosphorylase
Synonyms:
5'-Methylthioadenosine phosphorylase (MTAP) | MSAP | MTA phosphorylase | MTAP | MTAP_HUMAN | MTAPase | Methylthioadenosine Phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase
Type:
Enzyme
Mol. Mass.:
31239.23
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
283
Sequence:
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
  
Inhibitor
Name:
BDBM50170092
Synonyms:
1-(4-Amino-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-ylmethyl)-4-(4-chloro-phenylsulfanylmethyl)-pyrrolidin-3-ol | CHEMBL365813
Type:
Small organic molecule
Emp. Form.:
C18H22ClN5OS
Mol. Mass.:
391.918
SMILES:
NC1NC=Nc2c(CN3CC(O)C(CSc4ccc(Cl)cc4)C3)c[nH]c12 |c:3|
Structure:
Search PDB for entries with ligand similarity: