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Target
Neuropeptide Y receptor type 5
Ligand
BDBM50163530
Substrate
n/a
Meas. Tech.
ChEMBL_305314 (CHEMBL831705)
IC50
69±n/a nM
Citation
 Torrens, A; Mas, J; Port, A; Castrillo, JA; Sanfeliu, O; Guitart, X; Dordal, A; Romero, G; Fisas, MA; Sánchez, E; Hernández, E; Pérez, P; Pérez, R; Buschmann, H Synthesis of new benzoxazinone derivatives as neuropeptide Y5 antagonists for the treatment of obesity. J Med Chem 48:2080-92 (2005) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_RAT | Neuropeptide Y receptor type 5 | Npy5r | Npyr5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50435.58
Organism:
Rat 6B
Description:
NPY-Y5 NPY5R Rat 6B::Q63634
Residue:
445
Sequence:
MEFKLEEHFNKTFVTENNTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLQPSKKSRNQAKTPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQGKHLAVPENPASVRSQLSPSSKVIPGVPICFEVKPEESSDAHEMRVKRSITRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM50163530
Synonyms:
2-[4-(6-Chloro-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperidin-1-yl]-N-(9-oxo-9H-fluoren-2-yl)-acetamide | CHEMBL555513
Type:
Small organic molecule
Emp. Form.:
C28H24ClN3O4
Mol. Mass.:
501.961
SMILES:
Clc1ccc2N(C3CCN(CC(=O)Nc4ccc5-c6ccccc6C(=O)c5c4)CC3)C(=O)OCc2c1
Structure:
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