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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50164608
Substrate
n/a
Meas. Tech.
ChEMBL_303347 (CHEMBL839662)
Ki
205±n/a nM
Citation
 Tatsumi, R; Fujio, M; Satoh, H; Katayama, J; Takanashi, S; Hashimoto, K; Tanaka, H Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand. J Med Chem 48:2678-86 (2005) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50164608
Synonyms:
(2S)-3'-(2-naphthyl)-2'H-spiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxazolidin]-2'-one | CHEMBL195801
Type:
Small organic molecule
Emp. Form.:
C19H20N2O2
Mol. Mass.:
308.3743
SMILES:
O=C1O[C@]2(CN1c1ccc3ccccc3c1)CN1CCC2CC1 |wD:3.2,(3.77,3.1,;2.81,1.89,;1.28,1.93,;.75,.48,;1.97,-.45,;3.25,.42,;4.79,.44,;5.53,1.77,;7.07,1.8,;7.86,.47,;9.39,.48,;10.18,-.82,;9.41,-2.18,;7.87,-2.19,;7.1,-.87,;5.56,-.89,;.75,-1.06,;-.58,-1.82,;-1.91,-1.06,;-1.91,.48,;-.58,1.26,;-1.21,.07,;-.09,-.57,)|
Structure:
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