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Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM50172395
Substrate
n/a
Meas. Tech.
ChEMBL_321244 (CHEMBL881779)
IC50
9.6±n/a nM
Citation
 Nicolaou, KC Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. J Med Chem 48:5613-38 (2005) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM50172395
Synonyms:
(1R,9S,12R,21S,22S,24S,27R)-1-Hydroxy-22-methoxy-17,21,27-trimethyl-12-phenethyl-20,28-dioxa-4,11,14,17-tetraaza-tricyclo[22.3.1.0*4,9*]octacosane-2,3,10,13,16,19-hexaone | CHEMBL371029
Type:
Small organic molecule
Emp. Form.:
C34H48N4O10
Mol. Mass.:
672.7657
SMILES:
CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)N[C@H](CCc2ccccc2)C(=O)NCC(=O)N(C)CC(=O)O[C@H]1C
Structure:
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