Reaction Details Report a problem with these data
Target
cGMP-gated cation channel alpha-1
Ligand
BDBM50172542
Substrate
n/a
Meas. Tech.
ChEMBL_320710 (CHEMBL881696)
Kd
4000000±n/a nM
Citation
 Strassmaier, T; Uma, R; Ghatpande, AS; Bandyopadhyay, T; Schaffer, M; Witte, J; McDougal, PG; Brown, RL; Karpen, JW Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies. J Med Chem 48:5805-12 (2005) [PubMed]  Article 
Target
Name:
cGMP-gated cation channel alpha-1
Synonyms:
CNCG | CNCG1 | CNGA1 | CNGA1_BOVIN | cGMP-gated cation channel alpha 1
Type:
PROTEIN
Mol. Mass.:
79603.33
Organism:
Bos taurus
Description:
ChEMBL_320711
Residue:
690
Sequence:
MKKVIINTWHSFVNIPNVVGPDVEKEITRMENGACSSFSGDDDDSASMFEESETENPHARDSFRSNTHGSGQPSQREQYLPGAIALFNVNNSSNKEQEPKEKKKKKKEKKSKPDDKNENKKDPEKKKKKEKDKDKKKKEEKGKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMIIARACFDELQSDYLEYWLAFDYLSDVVYLLDMFVRTRTGYLEQGLLVKEERKLIDKYKSTFQFKLDVLSVIPTDLLYIKFGWNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRISNLVMYIIIIIHWNACVYFSISKAIGFGNDTWVYPDVNDPDFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYFFVVADFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKGMLEEKGKQILMKDGLLDINIANAGSDPKDLEEKVTRMESSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIDTEFSAIEGSGTESGPTDSTQD
  
Inhibitor
Name:
BDBM50172542
Synonyms:
{2-[4-(4-Acetylamino-butylamino)-benzoyloxy]-ethyl}-dimethyl-ammonium
Type:
Small organic molecule
Emp. Form.:
C17H28N3O3
Mol. Mass.:
322.422
SMILES:
C[NH+](C)CCOC(=O)c1ccc(NCCCCNC(C)=O)cc1
Structure:
Search PDB for entries with ligand similarity: