Reaction Details Report a problem with these data
Target
Putative deoxyuridine triphosphatase
Ligand
BDBM50190545
Substrate
n/a
Meas. Tech.
ChEMBL_320883 (CHEMBL884808)
Ki
>1000000±n/a nM
Citation
Nguyen, C; Kasinathan, G; Leal-Cortijo, I; Musso-Buendia, A; Kaiser, M; Brun, R; Ruiz-Pérez, LM; Johansson, NG; González-Pacanowska, D; Gilbert, IH Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target. J Med Chem 48:5942-54 (2005) [PubMed] Article
More Info.:
Target
Name:
Putative deoxyuridine triphosphatase
Synonyms:
dUTP pyrophosphatase | dUTPase
Type:
PROTEIN
Mol. Mass.:
30347.26
Organism:
Leishmania major
Description:
ChEMBL_320883
Residue:
268
Sequence:
MKRARSANIPGAILHSLAELQDGLNAMIDPSWRAVRSLDNWALAITMESTELLDSYPWKWWKNLNATPDLANVRIELVDIFHFSLSGAMQMRSTPDDEIPAASLKPLKEVMTTFLPAKECTSDPYGFVFFPLTDTQNAIASFRNIIQLANAYRFDVIIECIIYAAEDLGFNLVAYYIAKHTLNCIRQLSGYKDGSYVKVNNGVEDNSLLHNCIKDVSLDEVLDADKYVQAWNSIMANVYEAFQIKESDRKDAERWFALAKENRLAIKA
Inhibitor
Name:
BDBM50190545
Synonyms:
1-((2R,4S,5R)-4-hydroxy-5-((triphenylsilyloxy)methyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | CHEMBL211446
Type:
Small organic molecule
Emp. Form.:
C27H26N2O5Si
Mol. Mass.:
486.5912
SMILES:
O[C@H]1C[C@@H](O[C@@H]1CO[Si](c1ccccc1)(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O