Reaction Details Report a problem with these data
Target
Putative deoxyuridine triphosphatase
Ligand
BDBM50173544
Substrate
n/a
Meas. Tech.
ChEMBL_320883 (CHEMBL884808)
Ki
>1000000±n/a nM
Citation
Nguyen, C; Kasinathan, G; Leal-Cortijo, I; Musso-Buendia, A; Kaiser, M; Brun, R; Ruiz-Pérez, LM; Johansson, NG; González-Pacanowska, D; Gilbert, IH Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target. J Med Chem 48:5942-54 (2005) [PubMed] Article
More Info.:
Target
Name:
Putative deoxyuridine triphosphatase
Synonyms:
dUTP pyrophosphatase | dUTPase
Type:
PROTEIN
Mol. Mass.:
30347.26
Organism:
Leishmania major
Description:
ChEMBL_320883
Residue:
268
Sequence:
MKRARSANIPGAILHSLAELQDGLNAMIDPSWRAVRSLDNWALAITMESTELLDSYPWKWWKNLNATPDLANVRIELVDIFHFSLSGAMQMRSTPDDEIPAASLKPLKEVMTTFLPAKECTSDPYGFVFFPLTDTQNAIASFRNIIQLANAYRFDVIIECIIYAAEDLGFNLVAYYIAKHTLNCIRQLSGYKDGSYVKVNNGVEDNSLLHNCIKDVSLDEVLDADKYVQAWNSIMANVYEAFQIKESDRKDAERWFALAKENRLAIKA
Inhibitor
Name:
BDBM50173544
Synonyms:
CHEMBL198661 | Phosphoric acid 5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl ester diphenyl ester
Type:
Small organic molecule
Emp. Form.:
C21H19N2O7P
Mol. Mass.:
442.3585
SMILES:
O=c1ccn(C2OC(COP(=O)(Oc3ccccc3)Oc3ccccc3)C=C2)c(=O)[nH]1 |c:28|