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Target
Putative deoxyuridine triphosphatase
Ligand
BDBM50173559
Substrate
n/a
Meas. Tech.
ChEMBL_320883 (CHEMBL884808)
Ki
>1000000±n/a nM
Citation
 Nguyen, C; Kasinathan, G; Leal-Cortijo, I; Musso-Buendia, A; Kaiser, M; Brun, R; Ruiz-Pérez, LM; Johansson, NG; González-Pacanowska, D; Gilbert, IH Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target. J Med Chem 48:5942-54 (2005) [PubMed]  Article 
Target
Name:
Putative deoxyuridine triphosphatase
Synonyms:
dUTP pyrophosphatase | dUTPase
Type:
PROTEIN
Mol. Mass.:
30347.26
Organism:
Leishmania major
Description:
ChEMBL_320883
Residue:
268
Sequence:
MKRARSANIPGAILHSLAELQDGLNAMIDPSWRAVRSLDNWALAITMESTELLDSYPWKWWKNLNATPDLANVRIELVDIFHFSLSGAMQMRSTPDDEIPAASLKPLKEVMTTFLPAKECTSDPYGFVFFPLTDTQNAIASFRNIIQLANAYRFDVIIECIIYAAEDLGFNLVAYYIAKHTLNCIRQLSGYKDGSYVKVNNGVEDNSLLHNCIKDVSLDEVLDADKYVQAWNSIMANVYEAFQIKESDRKDAERWFALAKENRLAIKA
  
Inhibitor
Name:
BDBM50173559
Synonyms:
1-(5-Aminomethyl-4-hydroxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione | CHEMBL175267
Type:
Small organic molecule
Emp. Form.:
C9H13N3O4
Mol. Mass.:
227.2172
SMILES:
NCC1OC(CC1O)n1ccc(=O)[nH]c1=O
Structure:
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