Reaction Details Report a problem with these data
Target
Putative deoxyuridine triphosphatase
Ligand
BDBM50173532
Substrate
n/a
Meas. Tech.
ChEMBL_320883 (CHEMBL884808)
Ki
>1000000±n/a nM
Citation
Nguyen, C; Kasinathan, G; Leal-Cortijo, I; Musso-Buendia, A; Kaiser, M; Brun, R; Ruiz-Pérez, LM; Johansson, NG; González-Pacanowska, D; Gilbert, IH Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target. J Med Chem 48:5942-54 (2005) [PubMed] Article
More Info.:
Target
Name:
Putative deoxyuridine triphosphatase
Synonyms:
dUTP pyrophosphatase | dUTPase
Type:
PROTEIN
Mol. Mass.:
30347.26
Organism:
Leishmania major
Description:
ChEMBL_320883
Residue:
268
Sequence:
MKRARSANIPGAILHSLAELQDGLNAMIDPSWRAVRSLDNWALAITMESTELLDSYPWKWWKNLNATPDLANVRIELVDIFHFSLSGAMQMRSTPDDEIPAASLKPLKEVMTTFLPAKECTSDPYGFVFFPLTDTQNAIASFRNIIQLANAYRFDVIIECIIYAAEDLGFNLVAYYIAKHTLNCIRQLSGYKDGSYVKVNNGVEDNSLLHNCIKDVSLDEVLDADKYVQAWNSIMANVYEAFQIKESDRKDAERWFALAKENRLAIKA
Inhibitor
Name:
BDBM50173532
Synonyms:
1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluoro-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione | CHEMBL370908 | dUTPase inhibitor, 7
Type:
Small organic molecule
Emp. Form.:
C25H29FN2O4Si
Mol. Mass.:
468.5927
SMILES:
CC(C)(C)[Si](OCC1OC(CC1F)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1