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Target
Guanine nucleotide-binding protein G(i) subunit alpha-1
Ligand
BDBM50174647
Substrate
n/a
Meas. Tech.
ChEMBL_321104 (CHEMBL882870)
EC50
8600±n/a nM
Citation
 Manetti, D; Di Cesare Mannelli, L; Dei, S; Galeotti, N; Ghelardini, C; Romanelli, MN; Scapecchi, S; Teodori, E; Pacini, A; Bartolini, A; Gualtieri, F Design, synthesis, and preliminary pharmacological evaluation of a set of small molecules that directly activate gi proteins. J Med Chem 48:6491-503 (2005) [PubMed]  Article 
Target
Name:
Guanine nucleotide-binding protein G(i) subunit alpha-1
Synonyms:
GNAI1 | GNAI1_HUMAN | Guanine nucleotide-binding protein G(i), alpha-1 subunit
Type:
PROTEIN
Mol. Mass.:
40357.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_321104
Residue:
354
Sequence:
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
  
Inhibitor
Name:
BDBM50174647
Synonyms:
1-[4,4']Bipiperidinyl-1-yl-pentadecan-1-one; hydrochloride | CHEMBL536963
Type:
Small organic molecule
Emp. Form.:
C25H48N2O
Mol. Mass.:
392.6614
SMILES:
CCCCCCCCCCCCCCC(=O)N1CCC(CC1)C1CCNCC1
Structure:
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