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Target
C-C chemokine receptor type 1
Ligand
BDBM50174720
Substrate
n/a
Meas. Tech.
ChEMBL_325889 (CHEMBL863246)
IC50
3000±n/a nM
Citation
 Revesz, L; Bollbuck, B; Buhl, T; Eder, J; Esser, R; Feifel, R; Heng, R; Hiestand, P; Jachez-Demange, B; Loetscher, P; Sparrer, H; Schlapbach, A; Waelchli, R Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis. Bioorg Med Chem Lett 15:5160-4 (2005) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | CC-CKR-1 | CCR-1 | CCR1_MOUSE | CD_antigen=CD191 | Ccr1 | Cmkbr1 | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R
Type:
PROTEIN
Mol. Mass.:
40904.59
Organism:
Mus musculus
Description:
ChEMBL_1452291
Residue:
355
Sequence:
MEISDFTEAYPTTTEFDYGDSTPCQKTAVRAFGAGLLPPLYSLVFIIGVVGNVLVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDDWIFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPALYFFKAQWEFTHRTCSPHFPYKSLKQWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPSEKKVKAVRLIFAITLLFFLLWTPYNLSVFVSAFQDVLFTNQCEQSKQLDLAMQVTEVIAYTHCCVNPIIYVFVGERFWKYLRQLFQRHVAIPLAKWLPFLSVDQLERTSSISPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50174720
Synonyms:
(R)-N-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethylamino)-5-chlorophenyl)acetamide | CHEMBL370162
Type:
Small organic molecule
Emp. Form.:
C22H26ClFN4O2
Mol. Mass.:
432.919
SMILES:
C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)CNc1ccc(Cl)cc1NC(C)=O
Structure:
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