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Target3-oxoacyl-[acyl-carrier-protein] synthase 1
LigandBDBM50180124
Substrate/Competitorn/a
Meas. Tech.ChEMBL_330089
IC50>1000000±n/a nM
Citation Kim, PZhang, YMShenoy, GNguyen, QABoshoff, HIManjunatha, UHGoodwin, MBLonsdale, JPrice, ACMiller, DJDuncan, KWhite, SWRock, COBarry, CEDowd, CS Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli. J Med Chem49:159-71 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
3-oxoacyl-[acyl-carrier-protein] synthase 1
Name:3-oxoacyl-[acyl-carrier-protein] synthase 1
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:42605.82
Organism:Escherichia coli (strain K12)
Description:ChEMBL_330089
Residue:406
Sequence:
MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI
DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM
RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG
KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV
EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGT
STPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSIN
IEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD
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  Blast E-value cutoff:
BDBM50180124
NameBDBM50180124
Synonyms:3,5-dimethyl-4-hydroxy-5-(2-methoxybenzyl)-5H-thiophen-2-one | CHEMBL199810
TypeSmall organic molecule
Emp. Form.C14H16O3S
Mol. Mass.264.34
SMILESCOc1ccccc1CC1(C)SC(=O)C(C)C1=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a