Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50189849
Substrate
n/a
Meas. Tech.
ChEMBL_367041 (CHEMBL866804)
Ki
910±n/a nM
Citation
 Enguehard-Gueiffier, C; Hübner, H; El Hakmaoui, A; Allouchi, H; Gmeiner, P; Argiolas, A; Melis, MR; Gueiffier, A 2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist. J Med Chem 49:3938-47 (2006) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2 | 5-HT2A | 5HT2A_PIG | HTR2A | Serotonin 2a (5-HT2a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52679.13
Organism:
PIG
Description:
5-HT2 0 0::P50129
Residue:
470
Sequence:
MDVLCEENTSLSSPTNSFMQLNDDTRLYHNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQTGQKENSKQDDKATENDCTMVALGKQHSEDAPADNSNTVNEKVSCV
  
Inhibitor
Name:
BDBM50189849
Synonyms:
6-chloro-2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]imidazo[1,2-b]pyridazine | CHEMBL211135
Type:
Small organic molecule
Emp. Form.:
C17H17Cl2N5
Mol. Mass.:
362.256
SMILES:
Clc1ccc(cc1)N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Structure:
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