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Target
Heme oxygenase 1
Ligand
BDBM50183063
Substrate
n/a
Meas. Tech.
ChEMBL_368941 (CHEMBL869059)
IC50
1500±n/a nM
Citation
 Vlahakis, JZ; Kinobe, RT; Bowers, RJ; Brien, JF; Nakatsu, K; Szarek, WA Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. J Med Chem 49:4437-41 (2006) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HMOX1 | HMOX1_HUMAN | HO | HO-1 | HO1
Type:
PROTEIN
Mol. Mass.:
32822.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_368941
Residue:
288
Sequence:
MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM
  
Inhibitor
Name:
BDBM50183063
Synonyms:
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)-methyl]-4-methyl-1,3-dioxolane hydrochloride | 1-(((2R,4R)-2-(4-chlorophenethyl)-4-methyl-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | CHEMBL536056
Type:
Small organic molecule
Emp. Form.:
C16H19ClN2O2
Mol. Mass.:
306.787
SMILES:
C[C@@H]1CO[C@@](CCc2ccc(Cl)cc2)(Cn2ccnc2)O1
Structure:
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