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TargetCytochrome P450 2D6 (2D6)
LigandBDBM50410989
Substrate/Competitorn/a
Meas. Tech.ChEMBL_369356
IC50>30000±n/a nM
Citation Tatsumi, RFujio, MTakanashi, SNumata, AKatayama, JSatoh, HShiigi, YMaeda, JKuriyama, MHorikawa, TMurozono, THashimoto, KTanaka, H (R)-3'-(3-methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo[2,2,2]octane-3,5'-oxazolidin]-2'-one, a novel and potent alpha7 nicotinic acetylcholine receptor partial agonist displays cognitive enhancing properties. J Med Chem49:4374-83 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6 (2D6)
Name:Cytochrome P450 2D6
Synonyms:CYPIID6 | Cytochrome P450 2D6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50410989
NameBDBM50410989
Synonyms:CHEMBL2113233
TypeSmall organic molecule
Emp. Form.C18H20N2O3
Mol. Mass.312.363
SMILESCc1cc2cc(ccc2o1)N1C[C@@]2(CN3CCC2CC3)OC1=O |wD:12.23,TLB:11:12:16.15:18.19,THB:20:12:16.15:18.19,(.16,-7.7,;-.83,-6.52,;-.46,-5.02,;-1.76,-4.2,;-2.02,-2.69,;-3.46,-2.15,;-4.64,-3.15,;-4.38,-4.67,;-2.93,-5.19,;-2.36,-6.62,;-3.53,-.61,;-4.82,.23,;-4.42,1.72,;-4.69,3.12,;-6.05,3.73,;-7.52,3.08,;-7.32,1.7,;-5.78,2.36,;-5.53,4.26,;-5.98,5.37,;-2.88,1.79,;-2.33,.36,;-.84,-.05,)|
Structure
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