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Target
Kappa-type opioid receptor
Ligand
BDBM50190363
Substrate
n/a
Meas. Tech.
ChEMBL_376243 (CHEMBL869298)
Ki
>10000±n/a nM
Citation
 Zhang, Q; Keenan, SM; Peng, Y; Nair, AC; Yu, SJ; Howells, RD; Welsh, WJ Discovery of novel triazole-based opioid receptor antagonists. J Med Chem 49:4044-7 (2006) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50190363
Synonyms:
1-{3-[3-(tert-butyl) phenyl]-5-N,N-dimethylamino-(1,2,4-triazol-4-yl) }-3-phenol | CHEMBL377357
Type:
Small organic molecule
Emp. Form.:
C20H24N4O
Mol. Mass.:
336.4308
SMILES:
CN(C)c1nnc(-c2cccc(c2)C(C)(C)C)n1-c1cccc(O)c1
Structure:
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