Reaction Details Report a problem with these data
Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM21335
Substrate
n/a
Meas. Tech.
ChEMBL_381849 (CHEMBL869171)
Ki
29000±n/a nM
Citation
 Poduch, E; Bello, AM; Tang, S; Fujihashi, M; Pai, EF; Kotra, LP Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics. J Med Chem 49:4937-45 (2006) [PubMed]  Article 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
OMP decarboxylase | OMPDCase | Orotidine 5-phosphate decarboxylase | Orotidine Monophosphate Decarboxylase (ODCase) | PYRF_METTH | pyrF
Type:
Enzyme
Mol. Mass.:
24909.45
Organism:
Methanobacterium thermoautotrophicum
Description:
n/a
Residue:
228
Sequence:
MRSRRVDVMDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFRKRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFRGADSVRACLNVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIKDLLNP
  
Inhibitor
Name:
BDBM21335
Synonyms:
6-cyanouridine 5-monophosphate | C6-Uridine Derivative, 6 | JMC521648 Compound 34 | {[(2R,3S,4R,5R)-5-(6-cyano-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C10H12N3O9P
Mol. Mass.:
349.1907
SMILES:
O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1c(cc(=O)[nH]c1=O)C#N |r|
Structure:
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