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Target
P2Y purinoceptor 6
Ligand
BDBM50199173
Substrate
n/a
Meas. Tech.
ChEMBL_413303 (CHEMBL911824)
EC50
130±n/a nM
Citation
 El-Tayeb, A; Qi, A; Müller, CE Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem 49:7076-87 (2006) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 6
Synonyms:
P2RY6_RAT | P2ry6 | Pyrimidinergic receptor P2Y6
Type:
PROTEIN
Mol. Mass.:
36704.21
Organism:
Rattus norvegicus
Description:
ChEMBL_805344
Residue:
328
Sequence:
MERDNGTIQAPGLPPTTCVYREDFKRLLLPPVYSVVLVVGLPLNVCVIAQICASRRTLTRSAVYTLNLALADLLYACSLPLLIYNYARGDHWPFGDLACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWVVCGVVWLVVTAQCLPTAVFAATGIQRNRTVCYDLSPPILSTRYLPYGMALTVIGFLLPFTALLACYCRMARRLCRQDGPAGPVAQERRSKAARMAVVVAAVFVISFLPFHITKTAYLAVRSTPGVSCPVLETFAAAYKGTRPFASANSVLDPILFYFTQQKFRRQPHDLLQKLTAKWQRQRV
  
Inhibitor
Name:
BDBM50199173
Synonyms:
((2R,3S,4R,5R)-5-(5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate | 5-bromo-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-dione 5'-diphosphate | CHEMBL214698
Type:
Small organic molecule
Emp. Form.:
C9H13BrN2O12P2
Mol. Mass.:
483.057
SMILES:
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)n1cc(Br)c(=O)[nH]c1=O
Structure:
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