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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50241111
Substrate
n/a
Meas. Tech.
ChEMBL_423076 (CHEMBL910448)
IC50
38±n/a nM
Citation
 Laufer, SA; Ahrens, GM; Karcher, SC; Hering, JS; Niess, R Design, synthesis, and biological evaluation of phenylamino-substituted 6,11-dihydro-dibenzo[b,e]oxepin-11-ones and dibenzo[a,d]cycloheptan-5-ones: novel p38 MAP kinase inhibitors. J Med Chem 49:7912-5 (2006) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50241111
Synonyms:
3-(2-Amino-4-fluoro-phenylamino)-6H-dibenzo[b,e]oxepin-11-one | 3-(2-amino-4-fluoro-phenylamino)-6,11-dihydro-dibenzo[b,e]oxepin-11-one | CHEMBL218961
Type:
Small organic molecule
Emp. Form.:
C20H15FN2O2
Mol. Mass.:
334.3437
SMILES:
Nc1cc(F)ccc1Nc1ccc2c(OCc3ccccc3C2=O)c1
Structure:
Search PDB for entries with ligand similarity: