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TargetDihydroorotate dehydrogenase
LigandBDBM50201919
Substrate/Competitorn/a
Meas. Tech.ChEMBL_423284
IC50 7±n/a nM
Citation Kaila, NJanz, KDeBernardo, SBedard, PWCamphausen, RTTam, STsao, DHKeith, JCNickerson-Nutter, CShilling, AYoung-Sciame, RWang, Q Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J Med Chem50:21-39 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydroorotate dehydrogenase
Name:Dihydroorotate dehydrogenase
Synonyms:DHOdehase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH)
Type:Enzyme
Mol. Mass.:42881.33
Organism:Homo sapiens (Human)
Description:Q02127
Residue:395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50201919
NameBDBM50201919
Synonyms:6-fluoro-3-hydroxy-2-(4'-hydroxy-biphenyl-4-yl)-quinoline-4-carboxylic acid | CHEMBL386159
TypeSmall organic molecule
Emp. Form.C22H14FNO4
Mol. Mass.375.3493
SMILESOC(=O)c1c(O)c(nc2ccc(F)cc12)-c1ccc(cc1)-c1ccc(O)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a