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Target
Carbonic anhydrase 1
Ligand
BDBM10876
Substrate
n/a
Meas. Tech.
ChEMBL_423833 (CHEMBL911284)
Ki
55±n/a nM
Citation
 Nishimori, I; Minakuchi, T; Onishi, S; Vullo, D; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors. J Med Chem 50:381-8 (2007) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 1
Synonyms:
CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:
Enzyme
Mol. Mass.:
28873.37
Organism:
Homo sapiens (Human)
Description:
P00915
Residue:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
  
Inhibitor
Name:
BDBM10876
Synonyms:
4-(hydroxymethyl)benzene-1-sulfonamide | CHEMBL6919 | JMC522226 Compound 20 | JMC523116 Compound 20 | aromatic/heteroaromatic sulfonamide 21
Type:
Small organic molecule
Emp. Form.:
C7H9NO3S
Mol. Mass.:
187.216
SMILES:
NS(=O)(=O)c1ccc(CO)cc1
Structure:
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