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Target
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Ligand
BDBM50096873
Substrate
n/a
Meas. Tech.
ChEMBL_424366 (CHEMBL911297)
IC50
>50000±n/a nM
Citation
 Bachelier, A; Mayer, R; Klein, CD Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett 16:5605-9 (2006) [PubMed]  Article 
Target
Name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Synonyms:
EPT | Enoylpyruvate transferase | MURA_PSEAE | MurA (P. aeruginosa) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | UDP-N-acetylglucosamine enolpyruvyl transferase | murA
Type:
Protein
Mol. Mass.:
44640.67
Organism:
Pseudomonas aeruginosa (G-proteobacteria)
Description:
P. aeruginosa MurA
Residue:
421
Sequence:
MDKLIITGGNRLDGEIRISGAKNSALPILAATLLADTPVTVCNLPHLHDITTMIELFGRMGVQPIIDEKLNVEVDASSIKTLVAPYELVKTMRASILVLGPMLARFGEAEVALPGGCAIGSRPVDLHIRGLEAMGAQIEVEGGYIKAKAPAGGLRGGHFFFDTVSVTGTENLMMAAALANGRTVLQNAAREPEVVDLANCLNAMGANVQGAGSDTIVIEGVKRLGGARYDVLPDRIETGTYLVAAAATGGRVKLKDTDPTILEAVLQKLEEAGAHISTGSNWIELDMKGNRPKAVNVRTAPYPAFPTDMQAQFISMNAVAEGTGAVIETVFENRFMHVYEMNRMGAQILVEGNTAIVTGVPKLKGAPVMATDLRASASLVIAGLVAEGDTLIDRIYHIDRGYECIEEKLQLLGAKIRRVPG
  
Inhibitor
Name:
BDBM50096873
Synonyms:
(3aR,5S,8aR,9aR)-5,8a-dimethyl-3-methylidene-3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(3H)-one | Alantolactone | CHEMBL136356
Type:
Small organic molecule
Emp. Form.:
C15H20O2
Mol. Mass.:
232.3181
SMILES:
C[C@H]1CCC[C@]2(C)C[C@H]3OC(=O)C(=C)[C@H]3C=C12 |r,t:16|
Structure:
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