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Target
UDP-glucose 4-epimerase
Ligand
BDBM50194603
Substrate
n/a
Meas. Tech.
ChEMBL_424499 (CHEMBL911909)
IC50
12000±n/a nM
Citation
 Urbaniak, MD; Tabudravu, JN; Msaki, A; Matera, KM; Brenk, R; Jaspars, M; Ferguson, MA Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorg Med Chem Lett 16:5744-7 (2006) [PubMed]  Article 
Target
Name:
UDP-glucose 4-epimerase
Synonyms:
GALE | GALE_HUMAN
Type:
PROTEIN
Mol. Mass.:
38282.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_424499
Residue:
348
Sequence:
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
  
Inhibitor
Name:
BDBM50194603
Synonyms:
CHEMBL374772 | diamino(dimethylamino)methyl -((1R,4aS,4bS,8aS,10aS)-1-(2-(furan-3-yl)ethyl)-4b,8,8,10a-tetramethyl-decahydrophenanthren-2(1H,3H,4bH)-ylidene)methyl sulfate
Type:
Small organic molecule
Emp. Form.:
C28H47N3O5S
Mol. Mass.:
537.755
SMILES:
CN(C)C(N)(N)OS(=O)(=O)O\C=C1\CC[C@H]2[C@](C)(CC[C@H]3C(C)(C)CCC[C@]23C)[C@H]1CCc1ccoc1
Structure:
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