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Target
Cystathionine beta-lyase MetC
Ligand
BDBM50370856
Substrate
n/a
Meas. Tech.
ChEMBL_425863 (CHEMBL856866)
IC50
9000±n/a nM
Citation
 Ejim, LJ; Blanchard, JE; Koteva, KP; Sumerfield, R; Elowe, NH; Chechetto, JD; Brown, ED; Junop, MS; Wright, GD Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function. J Med Chem 50:755-64 (2007) [PubMed]  Article 
Target
Name:
Cystathionine beta-lyase MetC
Synonyms:
Beta-cystathionase | CBL | Cysteine lyase | METC_ECOLI | metC
Type:
PROTEIN
Mol. Mass.:
43211.38
Organism:
Escherichia coli K-12
Description:
ChEMBL_425863
Residue:
395
Sequence:
MADKKLDTQLVNAGRSKKYTLGAVNSVIQRASSLVFDSVEAKKHATRNRANGELFYGRRGTLTHFSLQQAMCELEGGAGCVLFPCGAAAVANSILAFIEQGDHVLMTNTAYEPSQDFCSKILSKLGVTTSWFDPLIGADIVKHLQPNTKIVFLESPGSITMEVHDVPAIVAAVRSVVPDAIIMIDNTWAAGVLFKALDFGIDVSIQAATKYLVGHSDAMIGTAVCNARCWEQLRENAYLMGQMVDADTAYITSRGLRTLGVRLRQHHESSLKVAEWLAEHPQVARVNHPALPGSKGHEFWKRDFTGSSGLFSFVLKKKLNNEELANYLDNFSLFSMAYSWGGYESLILANQPEHIAAIRPQGEIDFSGTLIRLHIGLEDVDDLIADLDAGFARIV
  
Inhibitor
Name:
BDBM50370856
Synonyms:
CHEMBL376005
Type:
Small organic molecule
Emp. Form.:
C28H14N4O10S2
Mol. Mass.:
630.562
SMILES:
[#8-]-[#7+](=O)-c1cc(cc2\[#6](=[#6](/C#N)C#N)-c3cc(cc(c3-c12)-[#7+](-[#8-])=O)S(=O)(=O)[#8]-c1ccccc1)S(=O)(=O)[#8]-c1ccccc1
Structure:
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