Target
L-selectin
Ligand
BDBM50205381
Substrate
n/a
Meas. Tech.
ChEMBL_428319 (CHEMBL917097)
IC50
37600±n/a nM
Citation
 Kranich, RBusemann, ASBock, DSchroeter-Maas, SBeyer, DHeinemann, BMeyer, MSchierhorn, KZahlten, RWolff, GAydt, EM Rational design of novel, potent small molecule pan-selectin antagonists. J Med Chem 50:1101-15 (2007) [PubMed]  Article 
Target
Name:
L-selectin
Synonyms:
LNHR | LYAM1 | LYAM1_HUMAN | Leukocyte adhesion molecule-1 | SELL | Selectin
Type:
PROTEIN
Mol. Mass.:
42187.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_200000
Residue:
372
Sequence:
MIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGKKSKRSMNDPY
  
Inhibitor
Name:
BDBM50205381
Synonyms:
(5-{2-[(3',4',5'-trihydroxy-biphenyl-3-carbonyl)-amino]-phenyl}-thiophen-2-yl)-acetic acid | CHEMBL374927
Type:
Small organic molecule
Emp. Form.:
C25H19NO6S
Mol. Mass.:
461.486
SMILES:
OC(=O)Cc1ccc(s1)-c1ccccc1NC(=O)c1cccc(c1)-c1cc(O)c(O)c(O)c1
Structure:
Search PDB for entries with ligand similarity: