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Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM14061
Substrate
n/a
Meas. Tech.
ChEMBL_430874 (CHEMBL913943)
Ki
4400±n/a nM
Citation
 Wu, Q; Gee, CL; Lin, F; Tyndall, JD; Martin, JL; Grunewald, GL; McLeish, MJ Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase. J Med Chem 48:7243-52 (2005) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:
Enzyme
Mol. Mass.:
30852.66
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
  
Inhibitor
Name:
BDBM14061
Synonyms:
8,9-Dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine | CHEMBL38681 | LY134046 | tetrahydrobenzazepine (THBA) deriv.
Type:
Small organic molecule
Emp. Form.:
C10H11Cl2N
Mol. Mass.:
216.107
SMILES:
Clc1ccc2CCCNCc2c1Cl
Structure:
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